Major Depression Clinical Trials

A double-blind, placebo-controlled study of an investigational medical food among SSRI-resistant outpatients with major depressive disorder (PI: E. Nelson)

Eligibility
• Adults (18-65 years old) with a diagnosis of current major depressive episode and currently treated with an SSRI antidepressant at adequate doses during the current episode for at least 8 weeks
• Outpatient

Patient Benefits
• Eligible participants may receive study medication and study-related procedures/visits at no cost, and compensation for time and travel

Contact Information
• Tracy Adleta
(513) 558-3249
Tracey.Adleta@uc.edu

A 12-week, double-blind, placebo-controlled trial of an investigational medication versus placebo in the treatment of binge eating disorder and comorbid depressive disorder (PI: E. Nelson)

Eligibility
• Adults (18-65 years old) with a diagnosis of binge eating disorder and a depressive disorder (major depression, dysthymia, minor depression, or brief recurrent depression)
• Outpatient

Patient Benefits
Eligible participants may receive study medication and study-related procedures/visits at no cost, and compensation for time and travel

Contact Information
Tracy Adleta
(513) 558-3249
Tracey.Adleta@uc.edu

Hypothalamic-pituitary-adrenal axis dysregulation and phenomenology of major depression: the HPA study (PI: E. Nelson)

Eligibility
• Adults (18-65 years old) with a diagnosis of current major depressive episode or adults (18-65 years old) who wish to participate as a healthy volunteer
• 2-day Inpatient stay on a research unit

Patient Benefits
Eligible participants may receive complete diagnostic interview and study-related procedures at no cost, and compensation for overnight stays, time, and travel

Contact Information
Tracy Adleta
(513) 558-3249
Tracey.Adleta@uc.edu

A pilot fMRI study of emotional processing in phenomenological subtypes of major depression (PI: E. Nelson)

Eligibility
• Adults (18-65 years old) with a diagnosis of current major depressive episode or adults (18-65 years old) who wish to participate as a healthy volunteer
• Outpatient
• MRI brain scan required

Patient Benefits
Eligible participants may receive complete diagnostic interview at no cost, and compensation for time and travel

Contact Information
Tracy Adleta
(513) 558-3249
Tracey.Adleta@uc.edu

Evaluation of omega-3 fatty acids as a treatment-adjunct in adolescent patients with major depressive disorder exhibiting partial response to SSRI medications:An open-label neuroimaging trial (PI: R. McNamara)

Eligibility
• Adolescents (12-18 years old) with a diagnosis of current major depressive episode and currently treated with an SSRI antidepressant at adequate doses
• Outpatient
• MRI brain scan required

Patient Benefits
Eligible participants may receive complete diagnostic interview, study medication, and study-related procedures/visits at no cost, and compensation for time and travel

Contact Information
Dr. Robert McNamara
(513) 558-5601
Robert.McNamara@uc.edu